Article
Different abilities of the four FGFRs to mediate FGF-1 translocation are linked to differences in the receptor C-terminal tail.
Journal of cell science - 15 Oct 2006
Sørensen Vigdis, Wiedlocha Antoni, Haugsten Ellen Margrethe, Khnykin Denis, Wesche Jørgen, Olsnes Sjur
Abstract excerpt
Members of the fibroblast growth factor family bind to one or more of the four closely related membrane-spanning FGF receptors. In addition to signaling through the receptors, exogenous FGF-1 and FGF-2 are endocytosed and translocated to the cytosol and nucleus where they stimulate RNA and DNA synthesis. Here we have studied the ability of the four FGF receptors to facilitate translocation of exogenous FGF-1 to...
Topics
- Amino Acid Sequence
- Animals
- Blotting, Western
- COS Cells
- Cattle
- Chlorocebus aethiops
- Electrophoresis, Polyacrylamide Gel
- Fibroblast Growth Factor 1
- HeLa Cells
- Humans