Article
A natural kinase-deficient variant of fibroblast growth factor receptor 1.
Biochemistry - 6 Aug 1996
Wang L Y, Edenson S P, Yu Y L, Senderowicz L, Turck C W
Abstract excerpt
A fibroblast growth factor receptor 1 variant missing 37 amino acids from the carboxy-terminal tyrosine kinase catalytic domain was discovered in human lung fibroblasts and several other human cell lines. The receptor variant binds specifically to acidic fibroblast growth factor but has no tyrosine kinase activity. It was found that cellular transfectants expressing the fibroblast growth factor receptor 1 variant...
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