Article
Mutants of basic fibroblast growth factor identify different cellular response programs.
Growth factors (Chur, Switzerland) - 1 Jan 1997
Leenders W P, van Hinsbergh V W, van Genesen S T, Schoenmakers J G, van Zoelen E J, Lubsen N H
Abstract excerpt
Mutations, expected to affect the intracellular routing, i.e. additional nuclear localization sequences (NLS; the natural 23 kDa isoform and a 17D27R mutant) and/or a deletion of amino acids 26-29 (23 delta 26-29 and 17 delta 26-29), were introduced in basic fibroblast growth factor (bFGF). The m...
Topics
- Animals
- COS Cells
- Cell Differentiation
- Cells, Cultured
- Crystallins
- DNA
- Endothelium, Vascular
- Epithelial Cells
- Fibroblast Growth Factor 2
- Humans
- Lens, Crystalline
- Mitogens
- Mutation
- Nuclear Localization Signals
- Rats
- Rats, Wistar
- Receptors, Cell Surface
- Receptors, Urokinase Plasminogen Activator