Article
Uncoupling of cell proliferation and differentiation activities of basic fibroblast growth factor.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Feb 2000
Bailly K, Soulet F, Leroy D, Amalric F, Bouche G
Abstract excerpt
FGF-2 exerts its pleiotropic effects on cell growth and differentiation by interacting with specific cell surface receptors. In addition, exogenously added FGF-2 is translocated from outside the cell to the nucleus during G1-S transition. In this study, we show that a single point mutation in FGF-2 (substitution of residue serine 117 by alanine) is sufficient to drastically reduce its mitogenic activity without...
Topics
- 3T3 Cells
- Animals
- Biological Transport
- Casein Kinase II
- Cattle
- Cell Compartmentation
- Cell Differentiation
- Cell Division
- Cell Nucleus
- Cricetinae
- Endothelium, Vascular
- Fibroblast Growth Factor 2
- Mice