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Article

Uncoupling of cell proliferation and differentiation activities of basic fibroblast growth factor.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Feb 2000

Bailly K, Soulet F, Leroy D, Amalric F, Bouche G

Abstract excerpt

FGF-2 exerts its pleiotropic effects on cell growth and differentiation by interacting with specific cell surface receptors. In addition, exogenously added FGF-2 is translocated from outside the cell to the nucleus during G1-S transition. In this study, we show that a single point mutation in FGF-2 (substitution of residue serine 117 by alanine) is sufficient to drastically reduce its mitogenic activity without...

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PMID: 10657989

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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