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Article

Cell transformation by fibroblast growth factors can be suppressed by truncated fibroblast growth factor receptors.

Molecular and cellular biology - 1 Nov 1994

Li Y, Basilico C, Mansukhani A

Abstract excerpt

Ligand-induced dimerization and transphosphorylation are thought to be important events by which receptor tyrosine kinases generate cellular signals. We have investigated the ability of signalling-defective, truncated fibroblast growth factor (FGF) receptors (FGFR-1 and FGFR-2) to block the FGF response in cells that express both types of endogenous FGF receptors. When these dominant negative receptors are...

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Identifiers

PMID: 7935480
DOI: 10.1128/mcb.14.11.7660-7669.1994
PMCID: PMC359302

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Source receipt: pubmed, retrieved 7 Sept 2026.

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