Cell transformation by fibroblast growth factors can be suppressed by truncated fibroblast growth factor receptors.

doi:10.1128/mcb.14.11.7660-7669.1994

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Article

Cell transformation by fibroblast growth factors can be suppressed by truncated fibroblast growth factor receptors.

Molecular and cellular biology - 1 Nov 1994

Li Y, Basilico C, Mansukhani A

Abstract excerpt

Ligand-induced dimerization and transphosphorylation are thought to be important events by which receptor tyrosine kinases generate cellular signals. We have investigated the ability of signalling-defective, truncated fibroblast growth factor (FGF) receptors (FGFR-1 and FGFR-2) to block the FGF r...

Topics

3T3 Cells
Animals
Binding Sites
CHO Cells
Cell Transformation, Neoplastic
Cricetinae
Fibroblast Growth Factors
Mice
Mutagenesis
Phenotype
Phosphorylation
Receptors, Fibroblast Growth Factor
Signal Transduction
Transfection

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