Article
Nuclear activities of basic fibroblast growth factor: potentiation of low-serum growth mediated by natural or chimeric nuclear localization signals.
Molecular biology of the cell - 1 May 1999
Arese M, Chen Y, Florkiewicz R Z, Gualandris A, Shen B, Rifkin D B
Abstract excerpt
Human basic fibroblast growth factor (FGF-2) occurs in four isoforms: a low molecular weight (LMW FGF-2, 18 kDa) and three high molecular weight (HMW FGF-2, 22, 22.5, and 24 kDa) forms. LMW FGF-2 is primarily cytoplasmic and functions in an autocrine manner, whereas HMW FGF-2s are nuclear and exert activities through an intracrine, perhaps nuclear, pathway. Selective overexpression of HMW FGF-2 forms in...
Topics
- 3T3 Cells
- Amino Acid Sequence
- Animals
- Apoptosis
- Bromodeoxyuridine
- Cell Division
- Cell Nucleus
- Cloning, Molecular
- Colony-Forming Units Assay
- DNA
- Fibroblast Growth Factor 2
- Humans
- Mice
- Molecular Sequence Data