Postirradiation growth in HAT medium fails to eliminate the delayed appearance of 6-thioguanine-resistant clones in EJ30 human epithelial cells.

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Article

Postirradiation growth in HAT medium fails to eliminate the delayed appearance of 6-thioguanine-resistant clones in EJ30 human epithelial cells.

Radiation research - 1 Feb 1998

Loucas B D, Cornforth M N

Abstract excerpt

The latent effects of radiation-induced damage include "delayed" mutations that arise de novo in the progeny of nonmutant cells. We investigated the early stages of delayed mutagenesis at the HPRT locus of EJ30 human epithelial cells that were exposed to 4 Gy of 137Cs gamma rays. To eliminate dir...

Topics

Cesium Radioisotopes
Culture Media
DNA Damage
Dose-Response Relationship, Radiation
Drug Resistance
Epithelial Cells
Gamma Rays
Humans
Hypoxanthine Phosphoribosyltransferase
Male
Mutation
Thioguanine
Time Factors
Tumor Cells, Cultured

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Open in PubMed

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PMID: 9457897

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9457897-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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