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Article

Evidence that most radiation-induced HPRT mutants are generated directly by the initial radiation exposure.

Mutation research - 3 May 1999

Leonhardt E A, Trinh M, Chu K, Dewey W C

Abstract excerpt

Radiation-induced HPRT mutants are generally assumed to arise directly from DNA damage that is misrepaired within a few hours after X-irradiation. However, there is the possibility that mutations result indirectly from radiation-induced genomic instability that may occur several days after the initial radiation exposure. The protocols that commonly employ a 5-7 day expression period to allow for expression of the...

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PMID: 10320747
DOI: 10.1016/s0027-5107(99)00080-9

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