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Article

Possible factors leading to a misjudgement of mutant frequencies in HPRT assay.

Mutation research - 5 Jul 1996

Khaidakov M, Glickman B W

Abstract excerpt

Interactions between cloning efficiency (CE) and mutant frequency (MF) in the HPRT clonal assay in in vitro study were analysed. In 12 separate reconstruction experiments with independent pairs of wild type (WT) and mutant (HPRT-) clones, the CE of WT cells (Group 1) and the recovery of mutant cells in absence (Group 2), as well as in the presence of non-irradiated (Group 3), or irradiated (Group 4) WT cells...

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PMID: 8692212
DOI: 10.1016/0027-5107(95)00253-7

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