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Article

Lower mutation frequencies are induced by ENU in undifferentiated embryonic cells than in differentiated cells of the mouse in vitro.

Mutation research - 1 Jun 1994

Sehlmeyer U, Wobus A M

Abstract excerpt

The pluripotent embryonic carcinoma cells of line P19 established from undifferentiated cells of the early mouse embryo and their differentiated progeny, the epithelioid ectoderm-like EPI-7 cells, were investigated for the induction of mutations at the HPRT locus by the alkylating agent N-ethyl-N...

Topics

Animals
Cell Differentiation
Drug Resistance
Embryo, Mammalian
Ethylnitrosourea
Mice
Mutagenicity Tests
Mutation
Thioguanine
Tumor Cells, Cultured

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 7515473
DOI: 10.1016/0165-7992(94)90070-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7515473-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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