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Article

Delayed appearance of lethal and specific gene mutations in irradiated mammalian cells.

International journal of radiation oncology, biology, physics - 1 Dec 1990

Little J B, Gorgojo L, Vetrovs H

Abstract excerpt

We have examined the occurrence of lethal and 6-thioguanine resistant (hprt locus) mutants among the progeny of irradiated CHO and BALB/3T3 cells. The expression of lethal mutations, as measured by a reduced cloning efficiency in the progeny cell population, was detected up to 30 mean population doublings after x-radiation. Preliminary evidence indicates that the expression of mutations at the hprt locus may also...

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Identifiers

PMID: 2262367
DOI: 10.1016/0360-3016(90)90354-m

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