Article
Effect of renin gene transfer on blood pressure in the spontaneously hypertensive rat.
Hypertension (Dallas, Tex. : 1979) - 1 Jan 1998
St Lezin E, Liu W, Wang N, Wang J M, Kren V, Zidek V, Zdobinska M, Krenova D, Bottger A, van Zutphen B F, Pravenec M
Abstract excerpt
To investigate whether molecular variation in the renin gene contributes to the greater blood pressure of spontaneously hypertensive rats (SHR) versus normotensive Brown Norway (BN) rats, we measured blood pressure in an SHR progenitor strain and an SHR congenic strain that are genetically identical except at the renin gene and an associated segment of chromosome 13 transferred from the BN strain. Backcross...
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