Article
The rat renin gene: assignment to chromosome 13 and linkage to the regulation of blood pressure.
Genomics - 1 Mar 1991
Pravenec M, Simonet L, Kren V, Kunes J, Levan G, Szpirer J, Szpirer C, Kurtz T
Abstract excerpt
It has recently been suggested that in the rat, sequence variation in the renin gene or closely linked genes may have the capacity to affect blood pressure and contribute to the pathogenesis of hypertension. To map the chromosomal location of the rat renin gene and to investigate its relationship to the inheritance of increased blood pressure, we studied a panel of rat x mouse somatic cell hybrids and a large set...
Topics
- Animals
- Base Sequence
- Blood Pressure
- Blotting, Southern
- Chromosome Mapping
- Crosses, Genetic
- Fumarate Hydratase
- Genetic Linkage
- Genetic Variation
- Hybrid Cells
- Mice