Article
Effects of renin gene transfer on blood pressure and renin gene expression in a congenic strain of Dahl salt-resistant rats.
The Journal of clinical investigation - 15 Jan 1996
St Lezin E M, Pravenec M, Wong A L, Liu W, Wang N, Lu S, Jacob H J, Roman R J, Stec D E, Wang J M, Reid I A, Kurtz T W
Abstract excerpt
To investigate whether a BP-regulatory locus exists in the vicinity of the renin locus on rat chromosome 13, we transferred this chromosome segment from the Dahl salt-sensitive (S) rat onto the genetic background of the Dahl salt-resistant (R) rat. In congenic Dahl R rats carrying the S renin gene and fed an 8% salt diet, systolic BP was significantly lower than in progenitor Dahl R rats: 127 +/- 1 mmHg versus...
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