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Article

Genetic isolation of a chromosome 1 region affecting blood pressure in the spontaneously hypertensive rat.

Hypertension (Dallas, Tex. : 1979) - 1 Oct 1997

St Lezin E, Liu W, Wang J M, Wang N, Kren V, Krenova D, Musilova A, Zdobinska M, Zidek V, Lau D, Pravenec M

Abstract excerpt

Recent linkage studies in the spontaneously hypertensive rat (SHR) suggest that a blood pressure regulatory gene or genes may be located on rat chromosome 1q. To investigate this possibility, we replaced a region of chromosome 1 in the SHR (defined by the markers D1Mit3 and Igf2) with the corresponding chromosome segment from the normotensive Brown-Norway (BN) strain. In male SHR congenic rats carrying the...

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PMID: 9336384
DOI: 10.1161/01.hyp.30.4.854

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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