Transfer of a salt-resistant renin allele raises blood pressure in Dahl salt-sensitive rats.

doi:10.1161/01.hyp.29.2.619

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Article

Transfer of a salt-resistant renin allele raises blood pressure in Dahl salt-sensitive rats.

Hypertension (Dallas, Tex. : 1979) - 1 Feb 1997

Jiang J, Stec D E, Drummond H, Simon J S, Koike G, Jacob H J, Roman R J

Abstract excerpt

To evaluate the role of the renin gene in the development of hypertension in Dahl salt-sensitive rats (SS/Jr/Hsd), we derived a congenic strain of rats homozygous for the salt-resistant renin allele (S/renrr) and compared them with a control strain homozygous for the salt-sensitive renin allele (...

Topics

Alleles
Animals
Blood Pressure
Captopril
Female
Genotype
Hypertension
Kidney Function Tests
Male
Phenotype
Proteins
Rats
Rats, Inbred Strains
Renin
Sodium Chloride
Sodium Chloride, Dietary
Urine

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