Article
Genetic isolation of a region of chromosome 8 that exerts major effects on blood pressure and cardiac mass in the spontaneously hypertensive rat.
The Journal of clinical investigation - 15 Feb 1997
Kren V, Pravenec M, Lu S, Krenova D, Wang J M, Wang N, Merriouns T, Wong A, St Lezin E, Lau D, Szpirer C, Szpirer J, Kurtz T W
Abstract excerpt
The spontaneously hypertensive rat (SHR) is the most widely studied animal model of essential hypertension. Despite > 30 yr of research, the primary genetic lesions responsible for hypertension in the SHR remain undefined. In this report, we describe the construction and hemodynamic characterizat...
Topics
- Animals
- Blood Pressure
- Chromosome Mapping
- Genotype
- Hypertension
- Male
- Molecular Sequence Data
- Organ Size
- Rats
- Rats, Inbred BN
- Rats, Inbred SHR
- Species Specificity