Article
Structural localization of the E3 glycoprotein in attenuated Sindbis virus mutants.
Journal of virology - 1 Feb 1998
Paredes A M, Heidner H, Thuman-Commike P, Prasad B V, Johnston R E, Chiu W
Abstract excerpt
We have determined the three-dimensional structures of the wild-type Sindbis virus and two of its mutants that retain the E3 sequence within PE2. Using difference imaging between these mutants and the wild-type virus, we have assigned a location for the 64-amino-acid sequence corresponding to E3 in the mutant spike complex. In the wild-type virus, the spike is composed of an E1-E2 heterotrimer. The E3 protein was...
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