Article
Role of N-linked glycosylation for sindbis virus infection and replication in vertebrate and invertebrate systems.
Journal of virology - 1 Jun 2009
Knight Ronald L, Schultz Kimberly L W, Kent Rebekah J, Venkatesan Meera, Griffin Diane E
Abstract excerpt
Each Sindbis virus (SINV) surface glycoprotein has two sites for N-linked glycosylation (E1 positions 139 and 245 [E1-139 and E1-245] and E2 positions 196 and 318 [E2-196 and E2-318]). Studies of SINV strain TE12 mutants with each site eliminated identified the locations of carbohydrates by cryo-electron microscopy (S. V. Pletnev et al., Cell 105:127-136, 2001). In the current study, the effects of altered...
Topics
- Alphavirus Infections
- Animals
- Cell Line
- Central Nervous System
- Cricetinae
- Culex
- Glycosylation
- Heparin
- Mutation
- Protein Binding
- Sindbis Virus
- Virion
- Virus Replication