Article
Lethality of PE2 incorporation into Sindbis virus can be suppressed by second-site mutations in E3 and E2.
Journal of virology - 1 Apr 1994
Heidner H W, McKnight K L, Davis N L, Johnston R E
Abstract excerpt
Sindbis virions contain two glycoproteins, E1 and E2. E2 is produced initially as a precursor, PE2, from which the amino-terminal 64 amino acids are cleaved by a cellular protease at a late stage in virion maturation. A mutation at E2 position 1 (Arg to Asn) was placed into Sindbis virus AR339 by...
Topics
- Amino Acid Sequence
- Animals
- CHO Cells
- Cricetinae
- Culicidae
- Glycosylation
- Mice
- Molecular Sequence Data
- Mutation
- Protein Precursors
- Protein Processing, Post-Translational
- Sequence Analysis, DNA