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Article

Mutations at the Alphavirus E1'-E2 Interdimer Interface Have Host-Specific Phenotypes.

Journal of virology - 9 Mar 2022

Ren Sophia C, Qazi Shefah A, Towell Brian, Wang Joseph C-Y, Mukhopadhyay Suchetana

Abstract excerpt

Alphaviruses are enveloped viruses transmitted by arthropod vectors to vertebrate hosts. The surface of the virion contains 80 glycoprotein spikes embedded in the membrane, and these spikes mediate attachment to the host cell and initiate viral fusion. Each spike consists of a trimer of E2-E1 heterodimers. These heterodimers interact at the following two interfaces: (i) the intradimer interactions between E2 and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35019719
DOI: 10.1128/jvi.02149-21
PMCID: PMC8906394

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