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The Alphavirus E3 Glycoprotein Functions in a Clade-Specific Manner

5 Oct 2012

Abstract excerpt

The 80 trimeric, glycoprotein spikes that cover the surface of alphavirus particles are required for mediating viral entry into a host cell. Spike assembly is a regulated process that requires interactions between five structural proteins, E3, E2, 6K and its translational frameshift product TF, and E1. E3 is a small, ∼65-amino-acid glycoprotein that has two known functions: E3 serves as the signal sequence for...

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PMID: 23035234
DOI: 10.1128/jvi.01805-12

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