Article
A pseudo-revertant of a Sindbis virus 6K protein mutant, which corrects for aberrant particle formation, contains two new mutations that map to the ectodomain of the E2 glycoprotein.
Virology - 1 Feb 1995
Ivanova L, Lustig S, Schlesinger M J
Abstract excerpt
Most site-directed mutations in the gene encoding the small, membrane-associated 6K protein of Sindbis virus interfere selectively with virus assembly and budding. Particles are released that are aberrant in structure, with a single membrane enclosing multiple nucleocapsids. A revertant for the m...
Topics
- Alphavirus Infections
- Animals
- Base Sequence
- Cell Line
- Cells, Cultured
- Cricetinae
- Culicidae
- DNA Primers
- Genome, Viral
- Genotype
- Kidney
- Kinetics
- Mice
- Microscopy, Electron
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Mutation
- Neurons