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Article

Probing the early temporal and spatial interaction of the Sindbis virus capsid and E2 proteins with reverse genetics.

Journal of virology - 1 Nov 2012

Snyder Jonathan E, Berrios Christian J, Edwards Thomas J, Jose Joyce, Perera Rushika, Kuhn Richard J

Abstract excerpt

A 7-Å cryoelectron microscopy-based reconstruction of Sindbis virus (SINV) was recently generated. Fitting the crystal structure of the SINV capsid protein (Cp) into the density map revealed that the F2-G2 loop of the Cp was shifted away from cytoplasmic domain of E2 (cdE2) in the 7-Å reconstruction relative to its position in the Cp crystal structure. Furthermore, the reconstruction demonstrated that residue...

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Identifiers

PMID: 22951842
DOI: 10.1128/JVI.01220-12
PMCID: PMC3486501

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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