Article
Mutations in the endodomain of Sindbis virus glycoprotein E2 define sequences critical for virus assembly.
Journal of virology - 1 May 2006
West John, Hernandez Raquel, Ferreira Davis, Brown Dennis T
Abstract excerpt
Envelopment of Sindbis virus at the plasma membrane is a multistep process in which an initial step is the association of the E2 protein via a cytoplasmic endodomain with the preassembled nucleocapsid. Sindbis virus is vectored in nature by blood-sucking insects and grows efficiently in a number of avian and mammalian vertebrate hosts. The assembly of Sindbis virus, therefore, must occur in two very different...
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