Article

Mutations at the Alphavirus E2/E1 inter-dimer interface have host-specific phenotypes

2021-09-04

Abstract excerpt

<h4>ABSTRACT</h4> Alphaviruses are enveloped viruses transmitted by arthropod vectors to vertebrate hosts. The surface of the virion contains 80 glycoprotein spikes embedded in the membrane and these spikes mediate attachment to the host cell and initiate viral fusion. Each spike consists of a trimer of E2-E1 heterodimers. These heterodimers interact at two interfaces: (1) the intra-dimer interactions between E2...

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Literature Corpus work: 4a7e70b1-e2d5-5561-9aeb-c5f0d9b75221
DOI: 10.1101/2021.09.02.458808

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