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Article

Mutating conserved cysteines in the alphavirus e2 glycoprotein causes virus-specific assembly defects.

Journal of virology - 1 Mar 2012

Snyder Anthony J, Sokoloski Kevin J, Mukhopadhyay Suchetana

Abstract excerpt

There are 80 trimeric, glycoprotein spikes that cover the surface of an alphavirus particle. The spikes, which are composed of three E2 and E1 glycoprotein heterodimers, are responsible for receptor binding and mediating fusion between the viral and host-cell membranes during entry. In addition, the cytoplasmic domain of E2 interacts with the nucleocapsid core during the last stages of particle assembly, possibly...

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Identifiers

PMID: 22238319
DOI: 10.1128/JVI.06615-11
PMCID: PMC3302346

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Source receipt: pubmed, retrieved 7 Sept 2026.

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