Article
A 5.5-kb enhancer is both necessary and sufficient for regulation of Wnt-1 transcription in vivo.
Developmental biology - 15 Dec 1997
Danielian P S, Echelard Y, Vassileva G, McMahon A P
Abstract excerpt
Wnt-1 encodes a secreted signaling molecule which is required for development of the midbrain and anterior hindbrain in the mouse. Wnt-1 expression is initiated early in the development of the central nervous system in a region predicted to give rise to the midbrain. Later in development Wnt-1 expression is restricted to regions of the forebrain, midbrain, and spinal cord. Previous studies identified a 5.5-kb...
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