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Article

The widely used Wnt1-Cre transgene causes developmental phenotypes by ectopic activation of Wnt signaling.

Developmental biology - 15 Jul 2013

Lewis Ace E, Vasudevan Harish N, O'Neill Audrey K, Soriano Philippe, Bush Jeffrey O

Abstract excerpt

The Wnt1-Cre transgenic mouse line is extensively used in the study of the development of the neural crest and its derivatives and the midbrain. The Wnt1 gene has important developmental roles in formation of the midbrain-hindbrain boundary, regulation of midbrain size, and neurogenesis of ventral midbrain dopaminergic (mDA) neurons. Here, we report that Wnt1-Cre transgenic mice exhibit phenotypes in multiple...

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Identifiers

PMID: 23648512
DOI: 10.1016/j.ydbio.2013.04.026
PMCID: PMC3804302

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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