Article
Elements both 5' and 3' to the murine Hoxd4 gene establish anterior borders of expression in mesoderm and neurectoderm.
Mechanisms of development - 1 Sept 1997
Zhang F, Pöpperl H, Morrison A, Kovàcs E N, Prideaux V, Schwarz L, Krumlauf R, Rossant J, Featherstone M S
Abstract excerpt
In this report, we show that a lacZ reporter spanning 12.5 kb of murine Hoxd4 genomic DNA contains the major regulatory elements controlling Hoxd4 expression in the mouse embryo. Mutational analysis revealed multiple regulatory regions both 5' and 3' to the coding region. These include a 3' enhancer region required for expression in the central nervous system (CNS) and setting the anterior border in the paraxial...
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