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Article

The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain.

Cell - 21 Sept 1990

McMahon A P, Bradley A

Abstract excerpt

The Wnt-1 (int-1) proto-oncogene, which encodes a putative signaling molecule, is expressed exclusively in the developing central nervous system and adult testes. To examine the role of Wnt-1, we generated six independent embryonic stem cell lines in which insertion of a neoR gene by homologous recombination inactivated a Wnt-1 allele. Germline chimeras were generated from two lines, and progeny from matings...

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PMID: 2205396
DOI: 10.1016/0092-8674(90)90385-r

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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