Article
The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain.
Cell - 21 Sept 1990
McMahon A P, Bradley A
Abstract excerpt
The Wnt-1 (int-1) proto-oncogene, which encodes a putative signaling molecule, is expressed exclusively in the developing central nervous system and adult testes. To examine the role of Wnt-1, we generated six independent embryonic stem cell lines in which insertion of a neoR gene by homologous r...
Topics
- Alleles
- Animals
- Base Sequence
- Brain
- Cell Line
- Chimera
- Embryo, Mammalian
- Female
- Genotype
- Heterozygote
- Homozygote
- Male
- Mice
- Molecular Sequence Data
- Mutation
- Oligonucleotide Probes
- Polymerase Chain Reaction
- Protein-Tyrosine Kinases