Article
Hoxb-2 transcriptional activation in rhombomeres 3 and 5 requires an evolutionarily conserved cis-acting element in addition to the Krox-20 binding site.
The EMBO journal - 1 Oct 1996
Vesque C, Maconochie M, Nonchev S, Ariza-McNaughton L, Kuroiwa A, Charnay P, Krumlauf R
Abstract excerpt
Segmentation is a key feature of the development of the vertebrate hindbrain where it involves the generation of repetitive morphological units termed rhombomeres (r). Hox genes are likely to play an essential role in the specification of segmental identity and we have been investigating their re...
Topics
- Animals
- Base Sequence
- Binding Sites
- Chick Embryo
- Cloning, Molecular
- Conserved Sequence
- DNA
- DNA-Binding Proteins
- Early Growth Response Protein 2
- Enhancer Elements, Genetic
- Gene Expression Regulation, Developmental
- Genes, Homeobox
- Homeodomain Proteins
- Mice