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Article

Mutation of a putative nuclear receptor binding site abolishes activity of the nestin midbrain enhancer.

Biochimica et biophysica acta - 3 Jan 2003

Kappen Claudia, Yaworsky Paul J

Abstract excerpt

Regional differences in gene expression are critical to the proper development of specialized cell types in the nervous system. The ventral midbrain is the prominent source of dopaminergic neurons, which are affected in Parkinson's disease. We have recently identified a gene regulatory element that is specifically active in ventral midbrain neuroepithelium of developing embryos. This 204-bp transcriptional...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 12527431
DOI: 10.1016/s0167-4781(02)00588-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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