Article
Mutation of the Dictyostelium fbxA gene affects cell-fate decisions and spatial patterning.
Protist - 1 Oct 2003
Ennis Herbert L, Dao Dee N, Wu Mary Y, Kessin Richard H
Abstract excerpt
Cell-fate decisions and spatial patterning in Dictyostelium are regulated by a number of genes. Our studies have implicated a gene called fbxA, which codes for an F-box protein, in these pathways. The FbxA protein is one of the controls on a cAMP phosphodiesterase called RegA, mediating its degradation via ubiquitin-linked proteolysis. Using marked strains, we showed that the fbxA- mutant has defective cell-type...
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