Article
Periodic signaling controlled by an oscillatory circuit that includes protein kinases ERK2 and PKA.
Science (New York, N.Y.) - 7 May 2004
Maeda Mineko, Lu Sijie, Shaulsky Gad, Miyazaki Yuji, Kuwayama Hidekazu, Tanaka Yoshimasa, Kuspa Adam, Loomis William F
Abstract excerpt
Self-regulating systems often use robust oscillatory circuits. One such system controls the chemotactic signaling mechanism of Dictyostelium, where pulses of adenosine 3',5'-monophosphate (cAMP) are generated with a periodicity of 7 minutes. We have observed spontaneous oscillations in activation of the mitogen-activated protein (MAP) kinase ERK2 that occur in phase with peaks of cAMP, and we show that ERK2...
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