Impact of adjustments for intermediate phenotypes on the power to detect linkage.

doi:10.1002/(SICI)1098-2272(1997)14:6<749::AID-GEPI31>3.0.CO;2-O

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Article

Impact of adjustments for intermediate phenotypes on the power to detect linkage.

Genetic epidemiology - 1 Jan 1997

Arnett D K, Pankow J S, Atwood L D, Sellers T A

Abstract excerpt

Since the manifestation of a complex disease is likely to be influenced through multiple genetic and/or environmental pathways, it may be advantageous to adjust for these multiple factors in a genetic analysis of a complex quantitative trait. Sib-pair linkage analysis was performed on the simulat...

Topics

Chromosome Mapping
Female
Genetic Diseases, Inborn
Genetic Linkage
Humans
Male
Matched-Pair Analysis
Nuclear Family
Phenotype
Predictive Value of Tests
Quantitative Trait, Heritable
Statistics, Nonparametric

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