Article
Complete genomic screen for disease susceptibility loci in nuclear families.
Genetic epidemiology - 1 Jan 1999
Anderson J L, Hauser E R, Martin E R, Scott W K, Ashley-Koch A, Kim K J, Monks S A, Haynes C S, Speer M C, Pericak-Vance M A
Abstract excerpt
We performed genome-wide model dependent and independent analyses on a simulated data set of 400 families segregating for a rare disorder. Regions on chromosomes 1, 3, and 5 were consistently indicated across the various analyses performed. Follow-up analyses included stratification for locus heterogeneity and clinical phenotype and studies of gene x gene and gene x environment interaction. The region around...
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