Article
Assessing the effect of sampling strategies on the power of linkage analysis to identify pathway-specific loci underlying a complex disease.
Genetic epidemiology - 1 Jan 2001
Guo X, Lin Y C, Wang Y, Cheng L S, Yang H
Abstract excerpt
Using the simulated general population data sets, we first examined the effect of sampling strategies on the power of identifying linkage by selecting samples with (A) two affected sibs in a nuclear family and (B) one affected sib and one sib with an intermediate trait value in the upper quantiles. Second, we evaluated the improvement in power when analyzing correlated traits simultaneously. Under each selection...
Topics
- Chromosome Mapping
- Genetic Predisposition to Disease
- Genetic Testing
- Genetics, Population
- Humans
- Microsatellite Repeats
- Models, Genetic
- Quantitative Trait, Heritable
- Sampling Studies