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Article

Estimating the effective sample size in association studies of quantitative traits.

G3 (Bethesda, Md.) - 17 Jun 2021

Ziyatdinov Andrey, Kim Jihye, Prokopenko Dmitry, Privé Florian, Laporte Fabien, Loh Po-Ru, Kraft Peter, Aschard Hugues

Abstract excerpt

The effective sample size (ESS) is a metric used to summarize in a single term the amount of correlation in a sample. It is of particular interest when predicting the statistical power of genome-wide association studies (GWAS) based on linear mixed models. Here, we introduce an analytical form of the ESS for mixed-model GWAS of quantitative traits and relate it to empirical estimators recently proposed. Using our...

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Identifiers

PMID: 33734375
DOI: 10.1093/g3journal/jkab057
PMCID: PMC8495748

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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