Article
Power to localize the major gene for disease liability is increased after accounting for the effects of related quantitative phenotypes.
Genetic epidemiology - 1 Jan 2001
Arya R, Duggirala R, Williams J T, Almasy L, Blangero J
Abstract excerpt
We used the simulated general population data for Genetic Analysis Workshop 12 to test whether power to localize the major gene for liability to disease is increased after accounting for the effects of correlated quantitative phenotypes. We performed the multipoint variance-component linkage analyses for the discrete trait twice: first analysis with age, sex, and EF1 as covariates, and the second analysis with...
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