Article
TAP- and tapasin-dependent HLA-E surface expression correlates with the binding of an MHC class I leader peptide.
Current biology : CB - 1 Jan 1998
Braud V M, Allan D S, Wilson D, McMichael A J
Abstract excerpt
BACKGROUND: The human major histocompatibility complex (MHC) class lb molecule HLA-E is transcribed in most tissues but little is known about its localisation within the cell. We have recently shown that HLA-E binds signal-sequence-derived peptides from human MHC class I molecules in vitro. RESULTS: Using a newly characterised antibody recognising HLA-E, we show that HLA-E is expressed at the cell surface. We...
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