Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Peptide Binding to HLA-E Molecules in Humans, Nonhuman Primates, and Mice Reveals Unique Binding Peptides but Remarkably Conserved Anchor Residues.

Journal of immunology (Baltimore, Md. : 1950) - 15 Nov 2020

Ruibal Paula, Franken Kees L M C, van Meijgaarden Krista E, van Loon Joeri J F, van der Steen Dirk, Heemskerk Mirjam H M, Ottenhoff Tom H M, Joosten Simone A

Abstract excerpt

Ag presentation via the nonclassical MHC class Ib molecule HLA-E, with nearly complete identity between the two alleles expressed in humans, HLA-E*01:01 and HLA-E*01:03, can lead to the activation of unconventional T cells in humans. Despite this virtual genetic monomorphism, differences in peptide repertoires binding to the two allelic variants have been reported. To further dissect and compare peptide binding...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens
Share to Conserved Sequence

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Histocompatibility Antigens Class I

Share to HLA-E Antigens

Share to Macaca fascicularis

Share to Peptides

Share to Recombinant Proteins

Share to T-Lymphocytes

Source

Open in PubMed Open full text

Identifiers

PMID: 33020145
DOI: 10.4049/jimmunol.2000810
PMCID: PMC7653511

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Peptide Binding to HLA-E Molecules in Humans, Nonhuman Primates, and Mice Reveals Unique Binding Peptides but Remarkably Conserved Anchor Residues.PMID 33020145Read ↗

Unveiling the Peptide Motifs of HLA-C and HLA-G from Naturally Presented Peptides and Generation of Binding Prediction Matrices.Semantic proximity Read ↗

Detailed and atypical HLA-E peptide binding motifs revealed by a novel peptide exchange binding assaySemantic proximity Read ↗

Uncovering the peptide-binding specificities of HLA-C: a general strategy to determine the specificity of any MHC class I molecule.Semantic proximity Read ↗

Pig-tailed macaques (Macaca nemestrina) possess six MHC-E families that are conserved among macaque species: implication for their binding to natural killer receptor variants.Semantic proximity Read ↗

Class I MHC-peptide interactions: structural requirements and functional implications.Semantic proximity Read ↗

The impact of human leukocyte antigen (HLA) micropolymorphism on ligand specificity within the HLA-B*41 allotypic family.Semantic proximity Read ↗

Specificity and degeneracy in peptide binding to HLA-B7-like class I molecules.Semantic proximity Read ↗

Several HLA alleles share overlapping peptide specificities.Semantic proximity Read ↗

Five HLA-DP molecules frequently expressed in the worldwide human population share a common HLA supertypic binding specificity.Semantic proximity Read ↗

Conserved MHC class I peptide binding motif between humans and rhesus macaques.Semantic proximity Read ↗

The pockets guide to HLA class I moleculesSemantic proximity Read ↗

The C-terminal extension landscape of naturally presented HLA-I ligandsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.