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Article

The diversity of the HLA-E-restricted peptide repertoire explains the immunological impact of the Arg107Gly mismatch.

Immunogenetics - 1 Jan 2016

Celik Alexander A, Kraemer Thomas, Huyton Trevor, Blasczyk Rainer, Bade-Döding Christina

Abstract excerpt

Human leukocyte antigen (HLA)-E molecules are potent inhibitors of NK cell-mediated killing. Low in polymorphisms, two alleles are widely expressed among diverse populations: HLA-E*01:01 and HLA-E*01:03. Both alleles are distinguished by one SNP resulting in the substitution Arg107Gly. Both alleles present a limited set of peptides derived from class I leader sequences physiologically; however, HLA-E*01:01...

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Identifiers

PMID: 26552660
DOI: 10.1007/s00251-015-0880-z
PMCID: PMC4701785

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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