Article
HLA-F Allele-Specific Peptide Restriction Represents an Exceptional Proteomic Footprint.
International journal of molecular sciences - 8 Nov 2019
Hò Gia-Gia T, Heinen Funmilola J, Blasczyk Rainer, Pich Andreas, Bade-Doeding Christina
Abstract excerpt
Peptide-dependent engagement between human leucocyte antigens class I (HLA-I) molecules and their cognate receptors has been extensively analyzed. HLA-F belongs to the non-classical HLA-Ib molecules with marginal polymorphic nature and tissue restricted distribution. The three common allelic variants HLA-F*01:01/01:03/01:04 are distinguished by polymorphism outside the peptide binding pockets (residue 50, α1 or...
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