Article
HLA-E restricted CD8+ T cell subsets are phenotypically altered in multiple sclerosis patients.
Multiple sclerosis (Houndmills, Basingstoke, England) - 1 Jun 2014
Pannemans Kim, Broux Bieke, Goris An, Dubois Bénédicte, Broekmans Tom, Van Wijmeersch Bart, Geraghty Daniel, Stinissen Piet, Hellings Niels
Abstract excerpt
BACKGROUND: The importance of Qa-1 restricted CD8(+) T cells in regulating autoreactive T cell responses has been demonstrated in animal models for autoimmune disorders, including multiple sclerosis (MS). OBJECTIVE: We hypothesize that their human variant, HLA-E restricted CD8(+) T cells, fulfills a similar regulatory role in man and that these cells are of importance in MS. METHODS: A large cohort of MS patients...
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