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Article

Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis.

Nature - 1 Jan 1998

Sakahira H, Enari M, Nagata S

Abstract excerpt

Various molecules such as cytokines and anticancer drugs, as well as factor deprivation, rapidly induce apoptosis (programmed cell death), which is morphologically characterized by cell shrinkage and the blebbing of plasma membranes and by nuclear condensation. Caspases, particularly caspase 3, are proteases that are activated during apoptosis and which cleave substrates such as poly(ADP-ribose) polymerase,...

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Identifiers

PMID: 9422513
DOI: 10.1038/34214

Genes

CAD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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