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Article

Engineered cellular gene-replacement platform for selective and inducible proteolytic profiling.

Proceedings of the National Academy of Sciences of the United States of America - 7 Jul 2015

Morgan Charles W, Diaz Juan E, Zeitlin Samantha G, Gray Daniel C, Wells James A

Abstract excerpt

Cellular demolition during apoptosis is completed by executioner caspases, that selectively cleave more than 1,500 proteins but whose individual roles are challenging to assess. Here, we used an optimized site-specific and inducible protease to examine the role of a classic apoptotic node, the caspase-activated DNase (CAD). CAD is activated when caspases cleave its endogenous inhibitor ICAD, resulting in the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26106156
DOI: 10.1073/pnas.1504141112
PMCID: PMC4500269

Genes

CAD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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