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Article

Salt is necessary for nucleosomal DNA fragmentation induced by caspase.

Biotechnology letters - 1 Dec 2005

Kim Bo-Eun, Lee Yun-Hee, Seong Changhyun, Shin Song Yub, Lee Jung Sup, Cho Byung Yun, Park Il-Seon

Abstract excerpt

For nucleosomal DNA fragmentation, one of the hallmarks of apoptosis, activated caspase, an apoptosis specific cysteine protease, is required to cleave ICAD/DFF45 that releases its complexed DNase, CAD/DFF40. The protein complex is located predominantly in the nuclei. Inconsistently, caspase alone cannot induce DNA fragmentation in the isolated nuclei without the addition of a cell extract or purified CAD/DFF40....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16328993
DOI: 10.1007/s10529-005-3906-z

Genes

CAD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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