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Article

A unique role of the DNA fragmentation factor in maintaining genomic stability.

Proceedings of the National Academy of Sciences of the United States of America - 31 Jan 2006

Yan Bin, Wang Huili, Peng Yuanlin, Hu Ye, Wang He, Zhang Xiuwu, Chen Qi, Bedford Joel S, Dewhirst Mark W, Li Chuan-Yuan

Abstract excerpt

DNA fragmentation is a hallmark of apoptosis (programmed cell death). However, the biological function of apoptotic DNA fragmentation remains unclear. Here, we show that DNA fragmentation factor plays an important role for maintaining genomic stability. Inhibition or loss of the DNA fragmentation factor (DFF)/caspase-activated DNase (CAD), whose nuclease activity is responsible for digesting genomic DNA during...

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Share to Apoptosis Regulatory Proteins
Share to Cell Transformation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Dose-Response Relationship, Radiation

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Source

Open in PubMed Open full text

Identifiers

PMID: 16432220
DOI: 10.1073/pnas.0507779103
PMCID: PMC1360538

Genes

CAD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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