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Article

The effect of ICAD-S on the formation and intracellular distribution of a nucleolytically active caspase-activated DNase.

Nucleic acids research - 15 Jul 2002

Scholz Sebastian Richard, Korn Christian, Gimadutdinow Oleg, Knoblauch Michael, Pingoud Alfred, Meiss Gregor

Abstract excerpt

We show here that co-expression of murine CAD with either ICAD-L or ICAD-S in Escherichia coli as well as mammalian cells leads to a functional DFF complex, which after caspase-3 activation releases a nucleolytically active DNase. The chaperone activity of ICAD-S is between one and two orders of magnitude less effective than that of ICAD-L, as deduced from cleavage experiments with different activated recombinant...

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Identifiers

PMID: 12136086
DOI: 10.1093/nar/gkf431
PMCID: PMC135751

Genes

CAD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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